AIDS Allergy and Rheumatology by Nancy E. Lane (auth.), Nancy E. Lane (eds.)

By Nancy E. Lane (auth.), Nancy E. Lane (eds.)

In Aids hypersensitive reaction and Rheumatology, scientific specialists survey the newest info to be had at the key rheumatic and allergic concerns that physicians face in treating the HIV-infected sufferer. Their articles concentrate on the rheumatologic and dermatologic manifestations of HIV-1 an infection, which come with arthritis, myopathies, vasculitis, sicca syndrome, different autoimmune phenomena, and psoriasis. in addition they research the query of allergy symptoms in HIV sufferers, together with drug allergic reaction, with exact consciousness given to opposed reactions to trimethoprim-sulfamethoxazole, the main usually prescribed anti-infective. functional recommendation for the prognosis and remedy of those difficulties is given in complete.

Aids hypersensitive reaction and Rheumatology bargains physicians a finished consultant to the analysis and remedy of the allergic, immunologic, and rheumatic problems in HIV sufferers. Authoritative and practice-oriented, the booklet is destined to turn into a typical source for all these treating AIDS sufferers today.

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These patients also present to physicians with proximal muscle weakness 3-21 mo after starting zidovudine. They typically have a two- to sixfold elevation in serum creatinine kinase levels, as well as proximal muscle weakness on physical examination (62-67). Pathologically, zidovudine-induced myositis is quite difficult to distinguish from idiopathic or HIV-associated polymyositis by light microscopy. It can, however, be distinguished by the appearance of "ragged-red" fibers, indicative of a mitochondrial abnormality, on electron microscopy.

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Lmmuno/. 151,5290-5300. 13. Stewart, A. , Stollar, B. , and Schwartz, R S. (1993),1. Exp. Med. 177,409-441. 14. , Barrett, K. , and Stollar, B. D. (1987), 1. lmmunol. 139,249,250. 15. , Barrett, K. , and Logtenberg, T. (1990),1. lmmunol. 145,2545-2553. 16. Pascual, V. and Capra, D. (1992), Arthritis Rheum. 35, 11-18. 17. Sanz, I. and Capra, J. D. (1988),1. lmmunol. 140,3283-3285. 18. van Es, J. , Meyling, F. H. J. , van de Akker, W. R. , Derksen, R. J. W. , and Logtenberg, T. (1991), J. Exp. Med.

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